Hendricks A A, Dec G W
Arch Dermatol. 1979 Jul;115(7):853-5.
Topical nitroglycerin ointment is among the most effective long-acting vasodilators currently available. We report two cases of contact dermatitis in which patch testing showed allergy to nitroglycerin-containing compounds. The severity of this dermatitis necessitated the discontinuation of topical nitroglycerin therapy in both patients. A potent corticosteroid cream applied once to previous nitroglycerin application sites prevented or minimized this dermatitis and enabled continuation of topical nitroglycerin therapy. Contact dermatitis due to topical nitroglycerin preparations may be more common than is presently realized.
局部用硝酸甘油软膏是目前可用的最有效的长效血管扩张剂之一。我们报告了两例接触性皮炎病例，其中斑贴试验显示对含硝酸甘油的化合物过敏。这种皮炎的严重程度使两名患者都不得不停止局部用硝酸甘油治疗。在先前使用硝酸甘油的部位涂抹一次强效皮质类固醇乳膏可预防这种皮炎或使其症状减轻，并能继续进行局部用硝酸甘油治疗。局部用硝酸甘油制剂引起的接触性皮炎可能比目前所认识到的更为常见。
