RelB核转位调节B细胞MHC分子、CD40表达及抗原呈递细胞功能。
RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.
作者信息
O'Sullivan B J, MacDonald K P, Pettit A R, Thomas R
机构信息
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia.
出版信息
Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11421-6. doi: 10.1073/pnas.97.21.11421.
Abstract
Mice with targeted RelB mutations demonstrated an essential role for RelB in immune responses and in myeloid dendritic cell differentiation. Human studies suggested a more global transcriptional role in antigen presentation. Burkitt lymphoma cell lines were used as a model to examine the role of RelB in antigen presentation. After transient transfection of BJAB with RelB, strong nuclear expression of RelB-p50 heterodimers was associated with increased APC function and expression of CD40 and MHC class I. Antisense RelB in DG75 reduced antigen-presenting capacity and CD40-mediated up-regulation of MHC molecules. The data indicate that RelB transcriptional activity directly affects antigen presentation and CD40 synthesis. Stimulation of RelB transcriptional activity may provide a positive feedback loop for facilitating productive APC/T cell interactions.
摘要
具有靶向RelB突变的小鼠表明RelB在免疫反应和髓样树突状细胞分化中起关键作用。人体研究表明RelB在抗原呈递中具有更广泛的转录作用。伯基特淋巴瘤细胞系被用作模型来研究RelB在抗原呈递中的作用。用RelB瞬时转染BJAB后，RelB-p50异二聚体的强核表达与抗原呈递细胞（APC）功能增强以及CD40和MHC I类分子的表达增加有关。DG75中的反义RelB降低了抗原呈递能力以及CD40介导的MHC分子上调。数据表明RelB转录活性直接影响抗原呈递和CD40合成。刺激RelB转录活性可能为促进有效的APC/T细胞相互作用提供一个正反馈回路。
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