Sahota T S, Latham R J, Linford R G, Taylor P M
Solid State Research Centre, Faculty of Applied Sciences, De Montfort University, Leicester, UK.
Drug Dev Ind Pharm. 2000 Oct;26(10):1039-44. doi: 10.1081/ddc-100100267.
Ionically conducting polymers, frequently known as polymer electrolytes, are potential candidates as hosts for drugs to be delivered iontophoretically. The iontophoretic delivery of lithium or lidocaine from polymer electrolyte films through a cellophane membrane was examined using different delivery current regimes. Thin, mechanically strong, polymer electrolyte films were fabricated from poly(ethylene oxide) (PEO) with lithium chloride or lidocaine hydrochloride. Experiments showed that iontophoretic transport of both lithium chloride and lidocaine hydrochloride might be achieved from these PEO-based films. Cation transport number determinations give values for PEO-based films of about 0.4 for lithium chloride systems and 0.12 for lidocaine hydrochloride systems. The mechanism of transport from these PEO-based polymer electrolyte films allows the delivery of ionic salts such as lithium chloride and lidocaine hydrochloride to be controlled solely by current, thus providing a system that can deliver precise amounts of drug.
离子导电聚合物，通常被称为聚合物电解质，是通过离子电渗疗法递送药物的潜在宿主候选物。使用不同的递送电流方案，研究了锂或利多卡因从聚合物电解质膜通过玻璃纸膜的离子电渗递送。由聚环氧乙烷（PEO）与氯化锂或盐酸利多卡因制备了薄的、机械强度高的聚合物电解质膜。实验表明，氯化锂和盐酸利多卡因的离子电渗转运都可以从这些基于PEO的膜中实现。阳离子迁移数测定得出，基于PEO的膜在氯化锂体系中的值约为0.4，在盐酸利多卡因体系中的值为0.12。这些基于PEO的聚合物电解质膜的转运机制使得诸如氯化锂和盐酸利多卡因等离子盐的递送仅通过电流即可控制，从而提供了一种能够递送精确剂量药物的系统。
