Kulkarni A R, Soppimath K S, Aralaguppi M I, Aminabhavi T M, Rudzinski W E
Department of Chemistry, Karnatak University, Dharwad, India.
Drug Dev Ind Pharm. 2000 Oct;26(10):1121-4. doi: 10.1081/ddc-100100278.
Polymeric sodium alginate microparticles were prepared by precipitating sodium alginate in methanol, followed by cross-linking with glutaraldehyde. The extent of cross-linking was controlled by the time of exposure to glutaraldehyde. The topology of microparticles was characterized by scanning electron microscopy (SEM), which indicated smooth surfaces. The equilibrium swelling experiments were carried out in water to observe the effect of cross-linking and drug loading for better utility of microparticles. It was found that swelling decreased, but drug loading increased, with an increase in cross-linking of the matrix.
通过在甲醇中沉淀海藻酸钠,然后与戊二醛交联来制备聚合海藻酸钠微粒。交联程度通过暴露于戊二醛的时间来控制。通过扫描电子显微镜(SEM)对微粒的拓扑结构进行表征,结果表明其表面光滑。在水中进行平衡溶胀实验,以观察交联和载药对微粒更好应用的影响。结果发现,随着基质交联度的增加,溶胀减小,但载药量增加。