从树脂结合的三肽固相合成双-2-咪唑烷硫酮。
Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides.
作者信息
Nefzi A, Giulianotti M A, Ong N A, Houghten R A
机构信息
Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.
出版信息
Org Lett. 2000 Oct 19;2(21):3349-50. doi: 10.1021/ol000225e.
PMID:11029207
Abstract
The exhaustive reduction of resin-bound tripeptides with borane afforded three secondary amines and one primary amine. The treatment of the solid-support polyamines with thiocarbonyldiimidazole afforded, following cleavage of the solid support, the corresponding bis-cyclic thiourea in good purity and yield.
摘要
用硼烷将树脂结合的三肽彻底还原，得到了三种仲胺和一种伯胺。用硫代羰基二咪唑处理固相载体多胺，在裂解固相载体后，得到了纯度和产率都很高的相应双环硫脲。
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