Kuenszberg E, Loeckinger A, Kleinsasser A, Lindner K H, Puehringer F, Hoermann C
Department of Anaesthesiology and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Eur J Anaesthesiol. 2000 Nov;17(11):662-4. doi: 10.1046/j.1365-2346.2000.00739.x.
Thirty-six unpremedicated women due for gynaecological surgery were examined for time-dependent prolongation of the QT interval in the electrocardiogram (ECG) before and after induction of anaesthesia using either sevoflurane or propofol. The conventional inhalational technique to induce anaesthesia with sevoflurane. ECG recordings were taken before, 2, 5 and 10 min after drug administration. Sevoflurane significantly lengthened (P < 0.001) the heart rate corrected QT interval within 10 min from 434 +/- 5 ms to 459 +/- 6 ms (mean +/- SEM). Already after 2 min of sevoflurane application a trend towards prolongation was visible. The critical value of 440 ms in the rate-corrected QT interval was exceeded in four patients in the sevoflurane group (n = 18) but in only in one patient in the propofol group (n = 18). Rate-corrected QT interval prolongation caused by sevoflurane needs to be recognized early in order to prevent the critical ventricular tachycardia torsade de pointes.
36名计划接受妇科手术且未使用术前药的女性，在使用七氟醚或丙泊酚进行麻醉诱导前后，接受了心电图（ECG）QT间期时间依赖性延长的检查。采用传统吸入技术用七氟醚诱导麻醉。在给药前、给药后2、5和10分钟记录心电图。七氟醚在10分钟内显著延长（P<0.001）心率校正QT间期，从434±5毫秒延长至459±6毫秒（平均值±标准误）。在应用七氟醚2分钟后就已可见延长趋势。七氟醚组（n=18）有4名患者心率校正QT间期超过440毫秒的临界值，但丙泊酚组（n=18）仅有1名患者超过该值。为预防严重的室性心动过速尖端扭转型室速，需要尽早识别由七氟醚引起的心率校正QT间期延长。
