Cattley S K, Williamson J F, Tay G K, Martinez O P, Gaudieri S, Dawkins R L
Centre for Molecular Immunology and Instrumentation, The University of Western Australia, Nedlands, Australia.
Eur J Immunogenet. 2000 Oct-Dec;27(5-6):397-426. doi: 10.1046/j.1365-2370.2000.00226.x.
Cell panels have been used extensively in studies of polymorphism and disease associations within the major histocompatibility complex (MHC), but the results from these panels require continuous updates with the increasing availability of novel data. We present here an updated table of the typings of the 10IHW and 4AOH panels. Local data included are HFE, HERV-K(C4) and six microsatellites telomeric of HLA-A. Typings for class I, MICA (PERB11.1), MICB (PERB11.2), XA, XB, LMP2 and 10 microsatellites reported by others have also been consolidated in this table. The tabulation shows that the length of conservation in the human MHC is even more extensive than previously thought. Human MHC ancestral haplotypes are inherited as a conserved region of genomic sequence spanning some 6-8 megabases from the HLA class II region and beyond the HLA class I region up to and including the HFE gene. Numerous examples of historical recombinations were also observed.
细胞板已广泛用于主要组织相容性复合体（MHC）内的多态性和疾病关联研究，但随着新数据的不断涌现，这些细胞板的结果需要持续更新。我们在此展示10IHW和4AOH细胞板分型的更新表格。纳入的本地数据包括HFE、HERV-K(C4)以及HLA-A端粒的六个微卫星。他人报告的I类、MICA（PERB11.1）、MICB（PERB11.2）、XA、XB、LMP2和10个微卫星的分型也已整合在该表格中。列表显示，人类MHC中的保守长度比之前认为的更为广泛。人类MHC祖先单倍型作为一个基因组序列保守区域遗传，该区域跨越约6 - 8兆碱基，从HLA II类区域开始，延伸至HLA I类区域之外，直至并包括HFE基因。还观察到许多历史重组的例子。
