Nishimura Y, Shimojima M, Miyazawa T, Sato E, Nakamura K, Izumiya Y, Ikeda Y, Mikami T, Takahashi E
Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
Eur J Immunogenet. 2000 Oct-Dec;27(5-6):427-30. doi: 10.1046/j.1365-2370.2000.00221.x.
We cloned the cDNAs encoding the feline homologues of B-lymphocyte activation antigens B7-1 (CD80) and B7-2 (CD86). We expressed recombinant feline CD80 and CD86 molecules by the baculovirus expression system, and demonstrated their binding ability to human CTLA4-murine immunoglobulin fusion protein.
我们克隆了编码B淋巴细胞激活抗原B7-1(CD80)和B7-2(CD86)猫科动物同源物的cDNA。我们通过杆状病毒表达系统表达了重组猫科动物CD80和CD86分子,并证明了它们与人CTLA4-鼠免疫球蛋白融合蛋白的结合能力。