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编码与人类CTLA4-Ig相互作用的猫B淋巴细胞活化抗原B7-1(CD80)和B7-2(CD86)同源物的cDNA的分子克隆。

Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human CTLA4-Ig.

作者信息

Nishimura Y, Shimojima M, Miyazawa T, Sato E, Nakamura K, Izumiya Y, Ikeda Y, Mikami T, Takahashi E

机构信息

Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.

出版信息

Eur J Immunogenet. 2000 Oct-Dec;27(5-6):427-30. doi: 10.1046/j.1365-2370.2000.00221.x.

DOI:10.1046/j.1365-2370.2000.00221.x
PMID:11029611
Abstract

We cloned the cDNAs encoding the feline homologues of B-lymphocyte activation antigens B7-1 (CD80) and B7-2 (CD86). We expressed recombinant feline CD80 and CD86 molecules by the baculovirus expression system, and demonstrated their binding ability to human CTLA4-murine immunoglobulin fusion protein.

摘要

我们克隆了编码B淋巴细胞激活抗原B7-1(CD80)和B7-2(CD86)猫科动物同源物的cDNA。我们通过杆状病毒表达系统表达了重组猫科动物CD80和CD86分子,并证明了它们与人CTLA4-鼠免疫球蛋白融合蛋白的结合能力。

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Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human CTLA4-Ig.编码与人类CTLA4-Ig相互作用的猫B淋巴细胞活化抗原B7-1(CD80)和B7-2(CD86)同源物的cDNA的分子克隆。
Eur J Immunogenet. 2000 Oct-Dec;27(5-6):427-30. doi: 10.1046/j.1365-2370.2000.00221.x.
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Porcine CTLA4-Ig lacks a MYPPPY motif, binds inefficiently to human B7 and specifically suppresses human CD4+ T cell responses costimulated by pig but not human B7.猪CTLA4-Ig缺乏MYPPPY基序,与人B7的结合效率低下,且特异性抑制由猪B7而非人B7共刺激的人CD4+T细胞反应。
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Sequence analyses of feline B7 costimulatory molecules.猫科动物B7共刺激分子的序列分析。
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Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis.CD28 对其同源反受体 CD80(B7.1)和 B70(B7.2)的差异识别:定点诱变分析
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