Sobels F H
Mutat Res. 1975 Aug;29(2):171-80. doi: 10.1016/0027-5107(75)90111-6.
A review is presented of the many conceptual contributions of Charlotte Auerbach to the development of the field of chemical mutagenesis during the past thirty years. The following aspects are discussed: (1) differences between the genetic effects of chemicals and X-rays; (2) mosaicism, delayed mutation and replicating instabilities; (3) mutation as a cellular process; (4) specificity; (5) dose-effect curves, and (6) correlation between different kinds of damage.
本文综述了夏洛特·奥尔巴赫在过去三十年中对化学诱变领域发展所做出的诸多概念性贡献。讨论了以下几个方面：（1）化学物质和X射线的遗传效应之间的差异；（2）嵌合体、延迟突变和复制不稳定性；（3）作为细胞过程的突变；（4）特异性；（5）剂量效应曲线，以及（6）不同类型损伤之间的相关性。
