Bennett M S
Ohio State University (OSU) of Pharmacy, Columbus, USA.
J Am Pharm Assoc (Wash). 2000 Sep-Oct;40(5 Suppl 1):S40-1.
Foot ulcers are a major cause of disability, morbidity, and mortality in people with diabetes. The three major etiological factors for diabetic foot ulcers are peripheral neuropathy, peripheral vascular disease, and infection. Tight control of blood glucose and proper foot care are essential for prevention of foot ulcers and lower extremity amputations. Treatment of lower extremity diabetic ulcers typically includes surgical debridement of the wound and appropriate oral or intravenous antibiotics. Becaplermin gel, a prescription, recombinant wound-healing therapy, may be used to promote healing of diabetic foot ulcers in select patients. Pharmacists can make a significant contribution to the prevention of diabetic foot ulcers and lower extremity amputations.
足部溃疡是糖尿病患者致残、发病和死亡的主要原因。糖尿病足部溃疡的三大病因是周围神经病变、周围血管疾病和感染。严格控制血糖和适当的足部护理对于预防足部溃疡和下肢截肢至关重要。下肢糖尿病溃疡的治疗通常包括伤口的手术清创以及适当的口服或静脉用抗生素。贝卡普勒明凝胶是一种处方重组伤口愈合疗法，可用于促进部分特定患者糖尿病足部溃疡的愈合。药剂师在预防糖尿病足部溃疡和下肢截肢方面可发挥重要作用。
