Comparison of two enteric coated microsphere preparations in the treatment of pancreatic exocrine insufficiency caused by cystic fibrosis.

作者信息

Santini B, Antonelli M, Battistini A, Bertasi S, Collura M, Esposito I, Di Febbraro L, Ferrari R, Ferrero L, Iapichino L, Lucidi V, Manca A, Pisconti C L, Pisi G, Raia V, Romano L, Rosati P, Grazioli I, Melzi G

机构信息

Department of Paediatric and Adolescence Science, University of Turin, Italy.

出版信息

Dig Liver Dis. 2000 Jun-Jul;32(5):406-11. doi: 10.1016/s1590-8658(00)80261-3.

DOI:10.1016/s1590-8658(00)80261-3

PMID:11030186

Abstract

BACKGROUND

Pancreatic exocrine insufficiency is a common condition in patients with cystic fibrosis. Large amounts of pancreatic enzyme supplements are required to reduce malabsorption but patient compliance is not always optimal.

AIMS

To compare patients' preference and the efficacy of two enteric coated microsphere preparations in patients with cystic fibrosis.

PATIENTS

Patients with pancreatic exocrine insufficiency due to cystic fibrosis.

METHODS

Patients were assigned to the crossover treatment with Creon or Pancrease for 1 week and then to the alternative treatment. Patients had to follow a fixed diet (at least 2 g fat/kg) and had to assume 1000 units lipase/g fat. The evaluation parameters were: patients' preference, acceptance of therapy, stool fat excretion, stool weight, gastrointestinal symptoms, and tolerance.

RESULTS AND CONCLUSIONS

Of the 33/60 patients who expressed a preference for one of the two treatments, 30 preferred Creon while only 3 patients preferred Pancrease (p<0.001). No difference between the two treatments was observed regarding stool characteristics, gastrointestinal symptoms and tolerance. The mean number of capsules taken daily was reduced by 35% with Creon. The results of this study showed a preference in favour of Creon probably due to the reduction of daily capsule intake of 35%, supporting digestion as well as Pancrease.

摘要