• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis, resolution, and absolute stereochemistry of (1R, 2S)-(+)-cis-1-methoxycarbonyl-2-methylcyclobutane.

作者信息

Baldwin JE, Burrell RC

机构信息

Department of Chemistry, Syracuse University, Syracuse, New York 13244, USA.

出版信息

J Org Chem. 2000 Oct 20;65(21):7139-44. doi: 10.1021/jo0009550.

DOI:10.1021/jo0009550
PMID:11031041
Abstract

Racemic cis-1-methoxycarbonyl-2-methylcyclobutane uncontaminated with the trans isomer was prepared efficiently in five steps; the corresponding amides from (R)-(-)-phenylglycinol were separated. An X-ray crystallographic structure determination of the amide from (+)-cis-1-methoxycarbonyl-2-methylcyclobutane showed that it was of (1R,2S) absolute stereochemistry, a revision of configurational assignment.

摘要

相似文献

1
Synthesis, resolution, and absolute stereochemistry of (1R, 2S)-(+)-cis-1-methoxycarbonyl-2-methylcyclobutane.
J Org Chem. 2000 Oct 20;65(21):7139-44. doi: 10.1021/jo0009550.
2
Preparation and configuration of racemic and optically active analgesic dialkylaminoalkylnaphthalenes.外消旋和旋光性止痛二烷基氨基烷基萘的制备与构型
Chirality. 1994;6(5):389-99. doi: 10.1002/chir.530060506.
3
(+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.(+)-甲基 (1R,2S)-2-[[4-(4-氯苯基)-4-羟基哌啶-1-基]甲基]-1-苯基环丙甲羧酸酯 [(+)-MR200] 衍生物作为强效和选择性 sigma 受体配体：立体化学和药理学性质。
J Med Chem. 2018 Jan 11;61(1):372-384. doi: 10.1021/acs.jmedchem.7b01584. Epub 2017 Dec 20.
4
Chiral dihydroxylation of acronycine: absolute configuration of natural cis-1,2-dihydroxy-1,2-dihydroacronycine and cytotoxicity of (1R,2R)- and (1S,2S)-1,2-diacetoxy-1,2-dihydroacronycine.山油柑碱的手性双羟基化反应：天然顺式 -1,2 - 二羟基 -1,2 - 二氢山油柑碱的绝对构型以及(1R,2R)-和(1S,2S)-1,2 - 二乙酰氧基 -1,2 - 二氢山油柑碱的细胞毒性
J Nat Prod. 1999 Mar;62(3):490-2. doi: 10.1021/np980420q.
5
Influence of N-terminal residue stereochemistry on the prolyl amide geometry and the conformation of 5-tert-butylproline type VI beta-turn mimics.N端残基立体化学对脯氨酰胺几何结构及5-叔丁基脯氨酸VI型β-转角模拟物构象的影响
J Pept Sci. 2001 Feb;7(2):92-104. doi: 10.1002/psc.297.
6
Stereo-Selective Preparation of Teneraic Acid, trans-(2S,6S)-Piperidine-2,6-dicarboxylic Acid, via Anodic Oxidation and Cobalt-Catalyzed Carbonylation.通过阳极氧化和钴催化羰基化立体选择性制备特内二酸，反式-(2S,6S)-哌啶-2,6-二甲酸
Chem Pharm Bull (Tokyo). 2017;65(9):854-861. doi: 10.1248/cpb.c17-00391.
7
Alterations in the stereochemistry of the kappa-selective opioid agonist U50,488 result in high-affinity sigma ligands.κ-选择性阿片样物质激动剂U50,488立体化学的改变产生了高亲和力的σ配体。
J Med Chem. 1989 Aug;32(8):1996-2002. doi: 10.1021/jm00128a050.
8
Synthesis, absolute configuration, and antibacterial activity of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H- benzo[ij]quinolizine-2-carboxylic acid.6,7-二氢-5,8-二甲基-9-氟-1-氧代-1H,5H-苯并[ij]喹嗪-2-羧酸的合成、绝对构型及抗菌活性
J Med Chem. 1987 May;30(5):839-43. doi: 10.1021/jm00388a016.
9
Synthesis, absolute configuration, and bacterial mutagenicity of the 8 stereoisomeric vicinal diol epoxides at the terminal benzo ring of carcinogenic dibenz[a,h]anthracene.致癌性二苯并[a,h]蒽末端苯环 8 个非对映立体二醇环氧化物的立体合成、绝对构型和细菌致突变性。
Chem Res Toxicol. 2011 Dec 19;24(12):2258-68. doi: 10.1021/tx200398b. Epub 2011 Nov 16.
10
Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative.对一种新型多聚甘胺衍生物的对映体高效液相色谱拆分和绝对立体化学构型确定。
J Pharm Biomed Anal. 2013 Mar 5;75:118-22. doi: 10.1016/j.jpba.2012.11.012. Epub 2012 Nov 21.