Rodger J, Bartlett C A, Beazley L D, Dunlop S A
Department of Zoology, The University of Western Australia, Nedlands, 6907, Australia.
Exp Neurol. 2000 Nov;166(1):196-200. doi: 10.1006/exnr.2000.7486.
During development, a graded expression of ephrin A2 has been implicated in retinotectal map formation. Here we have examined ephrin A2 expression during optic nerve regeneration in the mature goldfish. In the tecta of normal animals, a gradient of ephrin A2 expression is detected in cell bodies within the stratum fibrosum et griseum superficiale with more immunopositive cells caudally than rostrally. The gradient in the mature animal presumably reflects the plasticity associated with continued retinal and tectal neurogenesis. During optic nerve regeneration, expression throughout the tectum is increased by 1 month as a strong rostrocaudal gradient. The gradient declines to normal by 3 months. The up-regulation of ephrin A2 during optic nerve regeneration is likely to be instrumental in reestablishing the retinotectal map.
在发育过程中，ephrin A2的分级表达与视网膜顶盖图谱的形成有关。在此，我们研究了成熟金鱼视神经再生过程中ephrin A2的表达情况。在正常动物的顶盖中，在浅纤维灰质层的细胞体中检测到ephrin A2表达的梯度，尾侧的免疫阳性细胞比头侧更多。成熟动物中的这种梯度可能反映了与持续的视网膜和顶盖神经发生相关的可塑性。在视神经再生过程中，整个顶盖的表达在1个月时作为一个强烈的头尾梯度增加。到3个月时，该梯度降至正常。视神经再生过程中ephrin A2的上调可能有助于重新建立视网膜顶盖图谱。
