Fredberg J J
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
J Allergy Clin Immunol. 2000 Oct;106(4):615-24. doi: 10.1067/mai.2000.109429.
Airway hyperresponsiveness is one of the cardinal features of asthma but remains largely unexplained. The new concept of perturbed myosin binding within airway smooth muscle sheds light on the question of why airway narrowing is limited in the healthy lung and not in the asthmatic lung and points to unanticipated mechanisms through which lung development and allergic status may be major modulators of airway hyperresponsiveness.
气道高反应性是哮喘的主要特征之一，但在很大程度上仍未得到解释。气道平滑肌中肌球蛋白结合受到干扰这一新概念，揭示了为何在健康肺中气道狭窄受限而在哮喘肺中却不受限这一问题，并指出肺发育和过敏状态可能是气道高反应性主要调节因子的意外机制。
