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[用于测定糖化血红蛋白的比色法的临床评估——糖尿病检测]

[A clinical assessment of a colorimetric method for the determination of glycosylated hemoglobin--the diabetes test].

作者信息

Korolev V A, Pristupiuk A M, Glushkova O V, Dunaeva D D, Belokurenko V P, Malakhova O Iu, Sapegin I D

出版信息

Lik Sprava. 2000 Jul-Aug(5):96-8.

Abstract

135 patients with diabetes mellitus were studied for the level of glycated hemoglobin (GH) with the aid of the colorimetric method diabetes test involving the use of 0.3 N oxaloacetic acid, 0.06 M thiobarbituric acid, colorimetry on the spectrophotometer with the wavelength of 443 nm. No correlation was established or only weak relationship between the level of GH and chief clinical manifestations of diabetes mellitus, such as indices for metabolism, clinical presentation of the illness, degree of microangiopathy. There was no correlation between the above method and isoelectrofocusing in capillaries. Little value can be attached to GH level in controlling diabetes mellitus.

摘要

对135例糖尿病患者借助比色法糖尿病检测来研究糖化血红蛋白(GH)水平,该检测使用0.3N草酰乙酸、0.06M硫代巴比妥酸,在波长443nm的分光光度计上进行比色。未发现GH水平与糖尿病的主要临床表现之间存在相关性,或仅存在微弱关系,这些临床表现如代谢指标、疾病临床表现、微血管病变程度。上述方法与毛细管等电聚焦之间无相关性。GH水平在控制糖尿病方面价值不大。

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