Shibuya N, Tachibana H, Okuda B, Sugita M
Fifth Department of Internal Medicine, Hyogo College of Medicine.
Nihon Ronen Igakkai Zasshi. 2000 Jul;37(7):541-7. doi: 10.3143/geriatrics.37.541.
We conducted a neuropsychological comparison among cases with corticobasal degeneration (CBD; n = 8), those with progressive supranuclear palsy (PSP; n = 5) and healthy control subjects (n = 12) using an extensive neuropsychological battery assessing memory and executive functions. There were no significant differences among three groups for age, education, scores on the Mini-Mental State Examination and Zung's self-rating depression scale. Both patient groups showed retrieval impairment without recognition difficulties, and a dysexecutive syndrome. Along with those similarities, we observed some differences between CBD and PSP patients. Memory impairments in CBD patients were more marked than PSP patients in Rey's complex figure test, while they were less prominent in Rey's auditory verbal learning test. Perseverative errors of Nelson in Wisconsin card sorting test (Keio version) were more marked in CBD patients than in PSP patients. These two diseases showed memory and executive dysfunctions probably due to subcortico-frontal dysfunction. Some neuropsychological differences may help to distinguish CBD clinically from PSP.
我们使用一套广泛的神经心理测试组合对皮质基底节变性（CBD；n = 8）患者、进行性核上性麻痹（PSP；n = 5）患者和健康对照者（n = 12）进行了神经心理学比较，该测试组合用于评估记忆和执行功能。三组在年龄、教育程度、简易精神状态检查表得分和zung自评抑郁量表得分方面无显著差异。两个患者组均表现出回忆障碍但识别无困难，以及执行功能障碍综合征。除了这些相似之处，我们还观察到CBD患者和PSP患者之间存在一些差异。在雷伊复杂图形测试中，CBD患者的记忆损害比PSP患者更明显，而在雷伊听觉词语学习测试中则不那么突出。在威斯康星卡片分类测试（庆应义塾版）中，CBD患者的尼尔森持续性错误比PSP患者更明显。这两种疾病可能由于皮质下额叶功能障碍而出现记忆和执行功能障碍。一些神经心理学差异可能有助于在临床上区分CBD和PSP。
