Weidner W J
Section of Neurobiology, Physiology and Behavior, Division of Biological Sciences, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA.
J Comp Pathol. 2000 Aug-Oct;123(2-3):182-5. doi: 10.1053/jcpa.2000.0391.
In this study, scanning electron microscopy was used to examine the effects of hydrothorax on the morphology of the air sac visceral mesothelium of Gallus domesticus. Anaesthetized chickens were subjected to acute hydrodynamic pulmonary oedema induced by expansion of the extracellular fluid volume with an infusion of Ringer's solution equal to 6.5% of body weight. Tissue samples from the visceral surface of the abdominal air sacs near their ostia were obtained and fixed after death induced by anaesthetic overdose. These were compared with similar samples from control "non-volume-loaded" birds. The air sac visceral mesothelium of the volume-loaded animals presented an increased density of bulbous or swollen microvilli. These deformations were similar to changes reported in the visceral pleura of mammals subjected to hydrothorax, suggesting a commonality with regard to the role of these mesothelia in liquid clearance during pulmonary oedema.
在本研究中，使用扫描电子显微镜检查胸腔积液对家鸡气囊脏层间皮形态的影响。对麻醉的鸡输注相当于其体重6.5%的林格氏液，以扩张细胞外液体积，从而诱导急性流体动力性肺水肿。在麻醉过量致死后，从腹部气囊开口附近的脏面获取组织样本并进行固定。将这些样本与对照“未进行容量负荷”鸡的类似样本进行比较。容量负荷动物的气囊脏层间皮呈现出球状或肿胀微绒毛密度增加的现象。这些变形类似于在患有胸腔积液的哺乳动物脏层胸膜中报道的变化，表明这些间皮在肺水肿期间液体清除中的作用具有共性。
