Ohtsuka Y, Ogino T, Asano T, Hattori J, Ohta H, Oka E
Department of Child Neurology, Okayama University Medical School, Okayama, Japan.
Pediatr Neurol. 2000 Sep;23(3):202-6. doi: 10.1016/s0887-8994(00)00185-5.
We performed a clinical and electroencephalographic follow-up study on 25 patients with West syndrome that was responsive to vitamin B(6) (eight cryptogenic patients and 17 symptomatic patients) who were older than 3 years at the last follow-up. All cryptogenic patients and 13 symptomatic patients were seizure free at the last follow-up. All cryptogenic patients and seven symptomatic patients had intelligent quotient or developmental quotient scores of 75 or higher. The recurrence of clinical seizures was always associated with increases in epileptic discharges. We could successfully discontinue pyridoxal phosphate administration in four cryptogenic and four symptomatic patients who were 1 year, 8 months to 24 years old.
我们对25例对维生素B6有反应的韦斯特综合征患者（8例隐源性患者和17例症状性患者）进行了临床和脑电图随访研究，这些患者在最后一次随访时年龄超过3岁。所有隐源性患者和13例症状性患者在最后一次随访时无癫痫发作。所有隐源性患者和7例症状性患者的智商或发育商得分在75分及以上。临床癫痫发作的复发总是与癫痫放电增加相关。我们成功地停用了4例年龄在1岁8个月至24岁之间的隐源性患者和4例症状性患者的磷酸吡哆醛治疗。
