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男性骨质疏松症

[Osteoporosis in males].

作者信息

Audran M, Legrand E, Chappard D, Bigorgne J C, Basle M F

机构信息

Service de Rhumatologie, CHU, 49033 Angers Cedex.

出版信息

Ann Med Interne (Paris). 2000 Sep;151(5):399-407.

Abstract

A shorter life expectancy, a higher peak bone mass and the absence of distinct menopause equivalent explain the lower incidence of osteoporotic fractures in men. In contrast to women, osteoporosis in younger men is in most cases secondary. Causes such as prolonged glucocorticoid therapy, ethanol abuse, hypogonadism and gastrointestinal disorders are now well recognized. The impact of cigarette smoking, low calcium intake, vitamin D deficiency, hypercalciuria and thyrotoxicosis is more controversial but seems to constitute real risk factors for bone loss. Furthermore increased propensity to fall also plays a major role in fracture risk, particularly in alcoholic patients and in elderly men with neurologic disorders.

摘要

预期寿命较短、峰值骨量较高以及不存在明显的类似更年期的情况,这些因素解释了男性骨质疏松性骨折发病率较低的原因。与女性不同,年轻男性的骨质疏松症在大多数情况下是继发性的。长期糖皮质激素治疗、酗酒、性腺功能减退和胃肠道疾病等病因现已得到充分认识。吸烟、钙摄入量低、维生素D缺乏、高钙尿症和甲状腺毒症的影响更具争议性,但似乎确实是骨质流失的危险因素。此外,跌倒倾向增加在骨折风险中也起主要作用,尤其是在酗酒患者和患有神经系统疾病的老年男性中。

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