Dohen F, Montagne V, Lelieur E
Service de Pneumologie, Centre Hospitalier de Dunkerque 130, avenue Louis Herbeaux, B.P. 6.367, 59385 Dunkerque Cedex.
Rev Pneumol Clin. 2000 Sep;56(4):261-3.
We report the case of a patient who developed dantrolene-induced pleurisy. Dantrolene (Dantrium) is a muscle relaxing agent used for the treatment of spastic neurological manifestations which has known liver toxicity. Lung toxicity is rarely reported. Six cases of dantrolene-induced pleurisy occurring after chronic administration (> 60 days) have been described in the literature. The pleurisy is associated with pleural and peripheral eosinophilia. Spontaneous regression a few days after withdrawal and radiological cure a few months later is the rule. The precise mechanism of this drug-induced pleural reaction remains unknown.
我们报告了一例发生丹曲林诱发胸膜炎的患者。丹曲林（硝苯呋海因）是一种用于治疗痉挛性神经表现的肌肉松弛剂，已知具有肝毒性。肺部毒性鲜有报道。文献中描述了6例慢性给药（>60天）后发生的丹曲林诱发胸膜炎病例。该胸膜炎与胸膜及外周嗜酸性粒细胞增多有关。停药几天后自发消退，几个月后影像学治愈是常见情况。这种药物诱发的胸膜反应的确切机制尚不清楚。
