Ando E, Tanaka M, Yamashita F, Fukumori K, Sumie S, Yano Y, Sata M
The Second Department of Medicine, Kurume University School of Medicine, Fukuoka-ken, Japan.
J Clin Gastroenterol. 2000 Oct;31(3):247-9. doi: 10.1097/00004836-200010000-00015.
A case of hepatocellular carcinoma (HCC) complicated by tumor thrombosis of the main trunk is presented. Four courses of hepatic arterial infusion therapy, via a subcutaneously implanted injection port, were performed using cisplatin (10 mg for 1 hour on days 1-5) and 5-fluorouracil (250 mg for 5 hours on days 1-5). After four courses of the chemotherapy, marked reduction in size of HCC and the tumor markers were noted. The esophageal varices and ascites were improved after the chemotherapy with a recanalization of the left branch of the portal vein. The patient was doing well with a survival period of 28 months after the chemotherapy. These encouraging results suggested that the present therapy, based on the biochemical modulation, was a useful option for advanced HCC with portal hypertension due to tumor thrombosis of the main portal vein.
