Bates D, Mintz M
Foothills Medical Centre, Calgary, Alberta, Canada.
Pharmacotherapy. 2000 Oct;20(10):1208-15. doi: 10.1592/phco.20.15.1208.34584.
We cared for a patient who ingested an unknown amount of acetaminophen with zopiclone and warfarin. The only liver function test that was abnormal was an increased international normalized ratio (INR), which remained elevated despite treatment with subcutaneous phytonadione and a prolonged infusion of N-acetylcysteine. An interaction between acetaminophen and warfarin may have decreased the hepatic metabolism of warfarin. The patient received numerous antibiotics that may have contributed to the increased INR. The prolonged elevation of INR also may have been due to infrequent administration of phytonadione.
我们护理了一名摄入了未知量对乙酰氨基酚、佐匹克隆和华法林的患者。唯一异常的肝功能检查是国际标准化比值（INR）升高，尽管皮下注射了维生素K1以及长时间输注N - 乙酰半胱氨酸进行治疗，INR仍持续升高。对乙酰氨基酚和华法林之间的相互作用可能降低了华法林的肝脏代谢。该患者接受了多种抗生素治疗，这可能导致了INR升高。INR的持续升高也可能是由于维生素K1给药不频繁所致。
