爱泼斯坦-巴尔病毒、卡波西肉瘤相关疱疹病毒和赛米利疱疹病毒转化机制的比较分析。

Comparative analysis of the transforming mechanisms of Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, and Herpesvirus saimiri.

作者信息

Damania B, Jung J U

机构信息

Department of Microbiology and Molecular Genetics, New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA.

出版信息

Adv Cancer Res. 2001;80:51-82. doi: 10.1016/s0065-230x(01)80012-9.

DOI:10.1016/s0065-230x(01)80012-9

PMID:11034540

Abstract

Members of the gamma herpesvirus family include the lymphocryptoviruses (gamma-1 herpesviruses) and the rhadinoviruses (gamma-2 herpesviruses). Gammaherpesvirinae uniformly establish long-term, latent, reactivatable infection of lymphocytes, and several members of the gamma herpesviruses are associated with lymphoproliferative diseases. Epstein-Barr virus is a lymphocryptovirus, whereas Kaposi sarcoma-associated herpesvirus and Herpesvirus saimiri are members of the rhadinovirus family. Genes encoded by these viruses are involved in a diverse array of cellular signaling pathways. This review attempts to cover our understanding of how viral proteins deregulate cellular signaling pathways that ultimately contribute to the conversion of normal cells to cancerous cells.

摘要

γ疱疹病毒科的成员包括淋巴细胞隐病毒（γ-1疱疹病毒）和嗜淋巴细胞病毒（γ-2疱疹病毒）。γ疱疹病毒亚科一致建立淋巴细胞的长期潜伏、可再激活感染，并且γ疱疹病毒的几个成员与淋巴增殖性疾病相关。爱泼斯坦-巴尔病毒是一种淋巴细胞隐病毒，而卡波西肉瘤相关疱疹病毒和猴疱疹病毒是嗜淋巴细胞病毒家族的成员。这些病毒编码的基因参与多种细胞信号通路。本综述试图涵盖我们对病毒蛋白如何解除调节最终导致正常细胞转化为癌细胞的细胞信号通路的理解。