Fujisawa Y, Masuda K, Minakata H
Suntory Institute for Bioorganic Research, 1-1-1, Wakayamadai, Shimamoto, Mishima, Osaka 618-8503, Japan.
Peptides. 2000 Aug;21(8):1203-8. doi: 10.1016/s0196-9781(00)00260-6.
Fulicin is a D-amino acid-containing neuropeptide that has been thought to control male copulatory behavior in the land snail, Achatina fulica. In the present study, we demonstrated that the vagina and the oviduct of Achatina were densely innervated by fulicin-like immunoreactive neuronal fibers. We confirmed that fulicin was actually present in the vagina by mass spectrometry. Furthermore, fulicin showed a profound excitatory effect on contractions of the vagina and the oviduct. These results suggest that fulicin controls female egg-laying behavior as an excitatory neuropeptide regulating the female reproductive organs of the snail.
富利辛是一种含D-氨基酸的神经肽，一直被认为能控制非洲大蜗牛的雄性交配行为。在本研究中，我们证明了非洲大蜗牛的阴道和输卵管被富利辛样免疫反应性神经纤维密集支配。我们通过质谱法证实富利辛确实存在于阴道中。此外，富利辛对阴道和输卵管的收缩表现出显著的兴奋作用。这些结果表明，富利辛作为一种调节蜗牛雌性生殖器官的兴奋性神经肽，控制着雌性产卵行为。
