Nielsen P E, Leick V, Buchardt O
Acta Chem Scand B. 1975;29(6):662-6.
Some chloramphenicol analogues have been prepared in order to find reagents which could be used in a photoaffinity labelling study of the peptidayl transferase center of the E. coli ribosome. The compounds were tested for antibiotic activity in vitro in the "fragment reaction" assay, and for their ability to generate very reactive species upon irradiation.
为了找到可用于对大肠杆菌核糖体肽基转移酶中心进行光亲和标记研究的试剂，已制备了一些氯霉素类似物。这些化合物在“片段反应”测定中进行了体外抗生素活性测试，并测试了它们在辐照时产生高活性物质的能力。
