Chau K Y, Pretorius J M, Stewart A W
Department of Histopathology, Auckland Healthcare, Auckland, New Zealand.
Arch Pathol Lab Med. 2000 Oct;124(10):1476-9. doi: 10.5858/2000-124-1476-MIRCC.
To study retrospectively the identification, characteristics, and localization of myospherulosis in different types of renal cell carcinomas.
Twenty-seven consecutive renal cell carcinomas treated by radical nephrectomy in 1 year were studied. All the tumor and nontumor slides were examined for myospherulosis. The demographic data, histological type of renal cell carcinoma, Robson stage, and Fuhrman grades were recorded.
Myospherules were found in 10 cases. They were associated with the clear cell type and a higher nuclear grade. The cell type remained the only significant factor when these 2 factors were tested together with the tumor stage by logistic regression. Myospherulosis tended to be found in younger patients but was not associated with the sex or the side of the tumor. They were scattered within tumor cystic spaces or among sheets of tumor cells. Some of the myospherules might arise from histiocytes or even tumor cells. Compared with previous reports of myospherulosis associated with exogenous or endogenous lipid, the myospherules associated with renal cell carcinoma were smaller and more uniform in size. There is no associated fibrosis or foreign body giant cell reaction.
As far as we know, this is the first report of myospherulosis occurring in malignant tumors in human, and their associated features are different from those previously described for myospherulosis related to exogenous or endogenous lipid.
回顾性研究不同类型肾细胞癌中肌球孢子菌病的识别、特征及定位。
对1年内连续27例行根治性肾切除术治疗的肾细胞癌进行研究。检查所有肿瘤和非肿瘤切片以查找肌球孢子菌病。记录人口统计学数据、肾细胞癌的组织学类型、罗布森分期和富尔曼分级。
在10例中发现了肌球小体。它们与透明细胞型和较高的核分级相关。当通过逻辑回归将这两个因素与肿瘤分期一起测试时，细胞类型仍然是唯一的显著因素。肌球孢子菌病倾向于在年轻患者中发现，但与肿瘤的性别或部位无关。它们散在于肿瘤囊性间隙内或肿瘤细胞片之间。一些肌球小体可能起源于组织细胞甚至肿瘤细胞。与先前关于与外源性或内源性脂质相关的肌球孢子菌病的报道相比，与肾细胞癌相关的肌球小体更小且大小更均匀。没有相关的纤维化或异物巨细胞反应。
据我们所知，这是人类恶性肿瘤中发生肌球孢子菌病的首次报告，其相关特征与先前描述的与外源性或内源性脂质相关的肌球孢子菌病不同。
