一种新型人血清蛋白质国际参考制剂（标准物质470）对美国病理学家学会血浆蛋白检测结果的影响。
Effect of a new international reference preparation for proteins in human serum (certified reference material 470) on results of the College of American Pathologists Surveys for plasma proteins.
作者信息
Johnson A M, Whicher J T, Ledue T B, Carlström A, Itoh Y, Petersen P H
机构信息
Committee on Plasma Proteins, International Federation for Clinical Chemistry, Chapel Hill, NC, USA.
出版信息
Arch Pathol Lab Med. 2000 Oct;124(10):1496-501. doi: 10.5858/2000-124-1496-EOANIR.
OBJECTIVE
To examine the impact of a new international reference preparation for serum proteins on the among-manufacturer variance in the College of American Pathologists Surveys.
DATA SOURCE
The results of the Surveys for the years 1993-1998, supplied by the College of American Pathologists.
DATA EXTRACTION AND SYNTHESIS
Mean values for manufacturers' assays were compared for each protein in the quality control samples. Results were separated by the reported reference material from which values for calibrators had been transferred. Standard statistical parameters (means, standard deviations, and coefficients of variation) were calculated from the reported means.
CONCLUSIONS
Among-manufacturer coefficients of variation have dropped significantly for most serum proteins since the introduction of the new reference material. Possible reasons for continued differences are discussed.
目的
研究一种新的血清蛋白国际参考制剂对美国病理学家学会调查中各制造商之间差异的影响。
数据来源
由美国病理学家学会提供的1993 - 1998年调查结果。
数据提取与综合
比较了质量控制样本中各蛋白质的制造商检测均值。结果根据报告的用于转移校准品值的参考物质进行了区分。根据报告的均值计算了标准统计参数（均值、标准差和变异系数）。
结论
自引入新的参考物质以来，大多数血清蛋白的各制造商之间的变异系数已显著下降。讨论了持续存在差异的可能原因。
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