Johnson A M, Whicher J T, Ledue T B, Carlström A, Itoh Y, Petersen P H
Committee on Plasma Proteins, International Federation for Clinical Chemistry, Chapel Hill, NC, USA.
Arch Pathol Lab Med. 2000 Oct;124(10):1496-501. doi: 10.5858/2000-124-1496-EOANIR.
To examine the impact of a new international reference preparation for serum proteins on the among-manufacturer variance in the College of American Pathologists Surveys.
The results of the Surveys for the years 1993-1998, supplied by the College of American Pathologists.
Mean values for manufacturers' assays were compared for each protein in the quality control samples. Results were separated by the reported reference material from which values for calibrators had been transferred. Standard statistical parameters (means, standard deviations, and coefficients of variation) were calculated from the reported means.
Among-manufacturer coefficients of variation have dropped significantly for most serum proteins since the introduction of the new reference material. Possible reasons for continued differences are discussed.
研究一种新的血清蛋白国际参考制剂对美国病理学家学会调查中各制造商之间差异的影响。
由美国病理学家学会提供的1993 - 1998年调查结果。
比较了质量控制样本中各蛋白质的制造商检测均值。结果根据报告的用于转移校准品值的参考物质进行了区分。根据报告的均值计算了标准统计参数（均值、标准差和变异系数）。
自引入新的参考物质以来，大多数血清蛋白的各制造商之间的变异系数已显著下降。讨论了持续存在差异的可能原因。
