莱姆病螺旋体中，伯氏疏螺旋体饰胶蛋白聚糖结合蛋白A与外表面蛋白A之间疫苗协同作用在小鼠莱姆病模型中的证据。
Evidence for vaccine synergy between Borrelia burgdorferi decorin binding protein A and outer surface protein A in the mouse model of lyme borreliosis.
作者信息
Hanson M S, Patel N K, Cassatt D R, Ulbrandt N D
机构信息
MedImmune, Inc., Gaithersburg, Maryland 20878, USA.
出版信息
Infect Immun. 2000 Nov;68(11):6457-60. doi: 10.1128/IAI.68.11.6457-6460.2000.
Abstract
Mice immunized with either the predominantly vector-stage lipoprotein outer surface protein A (OspA) or the in vivo-expressed lipoprotein decorin binding protein A (DbpA) are protected against Borrelia burgdorferi challenge. DbpA-OspA combinations protected against 100-fold-higher challenge doses than did either single-antigen vaccine and conferred significant protection against heterologous B. burgdorferi, B. garinii, and B. afzelii isolates, suggesting that there is synergy between these two immunogens.
摘要
用主要为载体阶段的脂蛋白外表面蛋白A（OspA）或体内表达的脂蛋白核心蛋白聚糖结合蛋白A（DbpA）免疫的小鼠对伯氏疏螺旋体攻击具有抵抗力。与单一抗原疫苗相比，DbpA - OspA组合能抵抗高100倍的攻击剂量，并对异源的伯氏疏螺旋体、伽氏疏螺旋体和阿氏疏螺旋体分离株提供显著保护，这表明这两种免疫原之间存在协同作用。
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