疟原虫卵囊壳质酶的微线体转运至顶端复合体的电子致密区进行胞外分泌。
Micronemal transport of Plasmodium ookinete chitinases to the electron-dense area of the apical complex for extracellular secretion.
作者信息
Langer R C, Hayward R E, Tsuboi T, Tachibana M, Torii M, Vinetz J M
机构信息
World Health Organization Collaborating Center for Tropical Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609, USA.
出版信息
Infect Immun. 2000 Nov;68(11):6461-5. doi: 10.1128/IAI.68.11.6461-6465.2000.
Abstract
Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. gallinaceum are concentrated at the apical end of ookinetes. The chitinase PgCHT1 of P. gallinaceum is present within ookinete micronemes and subsequently becomes localized in the electron-dense area of the apical complex. These observations suggest a pathway by which ookinetes secrete proteins extracellularly.
摘要
疟原虫动合子分泌几丁质酶，以便在侵入上皮细胞的途中穿透蚊子中肠含几丁质的无细胞围食膜。几丁质酶可能是可用于阻断疟疾传播的靶点。我们在此证明，恶性疟原虫和鸡疟原虫的几丁质酶集中在动合子的顶端。鸡疟原虫的几丁质酶PgCHT1存在于动合子微线体中，随后定位于顶端复合体的电子致密区。这些观察结果提示了一种动合子向细胞外分泌蛋白质的途径。
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