鼠疫耶尔森菌YscG蛋白是一种类似于Syc的伴侣蛋白，可直接结合yscE。
Yersinia pestis YscG protein is a Syc-like chaperone that directly binds yscE.
作者信息
Day J B, Guller I, Plano G V
机构信息
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Florida 33101, USA.
出版信息
Infect Immun. 2000 Nov;68(11):6466-71. doi: 10.1128/IAI.68.11.6466-6471.2000.
Abstract
Pathogenic Yersinia species secrete virulence proteins, termed Yersinia outer proteins (Yops), upon contact with a eukaryotic cell. The secretion machinery is composed of 21 Yersinia secretion (Ysc) proteins. Yersinia pestis mutants defective in expression of YscG or YscE were unable to export the Yops. YscG showed structural and limited amino-acid-sequence similarities to members of the specific Yop chaperone (Syc) family of proteins. YscG specifically recognized and bound YscE; however, unlike previously characterized Syc substrates, YscE was not exported from the cell. These data suggest that YscG functions as a chaperone for YscE.
摘要
致病性耶尔森氏菌属物种在与真核细胞接触时会分泌被称为耶尔森氏菌外蛋白（Yops）的毒力蛋白。分泌机制由21种耶尔森氏菌分泌（Ysc）蛋白组成。在YscG或YscE表达上有缺陷的鼠疫耶尔森氏菌突变体无法输出Yops。YscG与特定Yop伴侣（Syc）蛋白家族成员在结构上有相似性且氨基酸序列相似性有限。YscG能特异性识别并结合YscE；然而，与先前鉴定的Syc底物不同，YscE并未从细胞中输出。这些数据表明YscG作为YscE的伴侣发挥作用。
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