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Downregulation of KRC induces proliferation, anchorage independence, and mitotic cell death in HeLa cells.

作者信息

Allen C E, Wu L C

机构信息

Program of Molecular, Cellular, and Developmental Biology, Ohio State University, Columbus, Ohio, 43210, USA.

出版信息

Exp Cell Res. 2000 Nov 1;260(2):346-56. doi: 10.1006/excr.2000.5029.

DOI:10.1006/excr.2000.5029
PMID:11035930
Abstract

The large zinc finger protein KRC regulates transcription of target genes via the kappaB gene enhancer element. As an attempt to investigate the cellular function of KRC, we have established cell lines stably transfected with KRC expression vectors. Introduction of a vector directing expression of a transcript antisense to KRC mRNAs in several mammalian cell lines resulted in accelerated proliferation. Furthermore, in HeLa cells, downregulation of KRC conferred anchorage-independent growth and promoted cell cycle progression without an intervening cytokinesis, culminating in the formation of multinucleated giant cells. Ultimately these cells died.

摘要

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