二氧化碳嗜纤维菌分离株对β-内酰胺类抗生素和β-内酰胺酶抑制剂的体外敏感性
In vitro susceptibilities of Capnocytophaga isolates to beta-lactam antibiotics and beta-lactamase inhibitors.
作者信息
Jolivet-Gougeon A, Buffet A, Dupuy C, Sixou J L, Bonnaure-Mallet M, David S, Cormier M
机构信息
Laboratoire de Microbiologie Pharmaceutique, UPRES-EA 1254, Université de Rennes I, 35000 Rennes, France.
出版信息
Antimicrob Agents Chemother. 2000 Nov;44(11):3186-8. doi: 10.1128/AAC.44.11.3186-3188.2000.
Abstract
The susceptibilities of 43 pharyngeal isolates of Capnocytophaga to beta-lactam antibiotics, alone or in combination with beta-lactamase inhibitors, were tested by an agar dilution method. The 34 beta-lactamase-positive strains were highly resistant to beta-lactams, but the intrinsic activities of clavulanate, tazobactam, and sulbactam against Capnocytophaga, even beta-lactamase producers, indicates that these beta-lactamase inhibitors could be used for empirical treatment of neutropenic patients with oral sources of infection.
摘要
采用琼脂稀释法检测了43株咽峡炎二氧化碳嗜纤维菌分离株对β-内酰胺类抗生素单独或与β-内酰胺酶抑制剂联合使用时的敏感性。34株β-内酰胺酶阳性菌株对β-内酰胺类高度耐药，但克拉维酸、他唑巴坦和舒巴坦对二氧化碳嗜纤维菌（即使是产β-内酰胺酶的菌株）的固有活性表明，这些β-内酰胺酶抑制剂可用于经验性治疗有口腔感染源的中性粒细胞减少患者。
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