Matas A J, Simmons R L, Buselmeier T J, Kjellstrand C M, Najarian J S
Am J Med. 1975 Dec;59(6):791-5. doi: 10.1016/0002-9343(75)90464-7.
Eleven selected patients with a history of cancer have received renal transplants. In three patients the malignancies were diagnosed and treated before renal failure developed. Two patients underwent bilateral nephrectomies for the treatment of bilateral renal malignancy. In six patients the malignancy developed while they were uremic, and they received transplants after treatment of the tumor. Recurrent tumor developed in only one of the 11 (9 per cent) patients after receiving the transplant. Thus, patients with a history of malignancy can receive a transplant without accelerating growth of the tumor. We recommend a minimum period of one year between tumor treatment and transplantation to observe for tumor recurrences or metastases. A longer period of observation may be necessary in patients who have tumors with a poorer prognosis.
11名有癌症病史的患者接受了肾移植。3名患者在肾衰竭发生前被诊断并治疗了恶性肿瘤。2名患者因双侧肾恶性肿瘤接受了双侧肾切除术。6名患者在尿毒症期发生了恶性肿瘤，他们在肿瘤治疗后接受了移植。11名患者中只有1名（9%）在接受移植后出现了肿瘤复发。因此，有恶性肿瘤病史的患者可以接受移植而不会加速肿瘤生长。我们建议在肿瘤治疗和移植之间至少间隔一年，以观察肿瘤复发或转移情况。对于预后较差的肿瘤患者，可能需要更长的观察期。
