Lindgren A
Medicinkliniken, Borås lasarett.
Lakartidningen. 2000 Sep 13;97(37):3987-92.
In the great majority of cases vitamin B12 deficiency is caused by chronic atrophic gastritis. This study has compared several different tests for the identification of patients for whom substitution therapy is needed or warranted. It is concluded that serum tests reflecting the state of the gastric body mucosa (serum pepsinogen A combined with serum gastrin or serum pepsinogen C) appear to be the logical first step in the workup of these patients in terms of high sensitivity and superior specificity as compared with other tests.
在绝大多数情况下，维生素B12缺乏是由慢性萎缩性胃炎引起的。本研究比较了几种不同的检测方法，以确定哪些患者需要或有必要进行替代治疗。得出的结论是，反映胃体黏膜状态的血清检测（血清胃蛋白酶原A联合血清胃泌素或血清胃蛋白酶原C），与其他检测相比，因其高敏感性和卓越的特异性，似乎是对这些患者进行检查的合理第一步。
