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补体C3和C4缺失血清中人类中性粒细胞对白色念珠菌的杀菌及吞噬活性(作者译)

[Fungicidal and phagocytic activity against "Candida albicans" of human neutrophils in serum depleted in C3 and C4 (author's transl)].

作者信息

Kernbaum S

出版信息

Ann Microbiol (Paris). 1975 Jan;126(1):75-81.

PMID:1103674
Abstract

Cases of systemic infections caused by C. albicans are increasing in number and the kidney appears to be involved more often than any other tissue. The renal medulla is especially susceptible to infection by C. albicans and by bacteria - Previous works has showed that this is essentially due to hyperosmolality and to inactivation of the complement system. Polymorphs are one of the main host defense mechanisms against C. albicans and the authors have studied their power of phagocytosis against Candida and fongicidal activity in serum depleted in C3 and C4. Both are found to be normal.

摘要

白色念珠菌引起的全身感染病例数量正在增加,而且肾脏似乎比其他任何组织更常受累。肾髓质尤其易受白色念珠菌和细菌感染——先前的研究表明,这主要是由于高渗性和补体系统的失活。多形核白细胞是抵御白色念珠菌的主要宿主防御机制之一,作者研究了它们在C3和C4缺乏的血清中对念珠菌的吞噬能力和杀真菌活性。结果发现两者均正常。

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