Raab W P, Gmeiner B M
Arch Dermatol Res (1975). 1975 Sep 12;253(2):113-8. doi: 10.1007/BF00582063.
Betamethasone, betamethasone-17-valerate, betamethasone-17-benzoate, and betamethasone-17,21-diproprionate were investigated for their inhbitory action on glucose-beta-phosphate dehydrogenase (G-6-PDH) activity (pure enzyme from yeast, enzyme from human skin homogenate). Between these four compounds, marked differences were encountered which could not be attributed to the presence of an esterified or unesterified steroid. According to these data it does not seem to be justified to consider betamethasone esters simply as the transport forms of the topically inactive betamethasone but one must consider the betamethasone esters having biochemical actions of their own.
对倍他米松、戊酸倍他米松、苯甲酸倍他米松和二丙酸倍他米松对葡萄糖 -β -磷酸脱氢酶（G - 6 - PDH）活性（来自酵母的纯酶、人皮肤匀浆中的酶）的抑制作用进行了研究。在这四种化合物之间，发现了显著差异，这些差异不能归因于酯化或未酯化类固醇的存在。根据这些数据，将倍他米松酯简单地视为局部无活性的倍他米松的转运形式似乎不合理，而必须考虑倍他米松酯自身具有生化作用。
