Chang Y C, Wang T Y, Tzen C Y
Department of Anatomic Pathology, Taipei Municipal Ho-Ping Hospital, Taiwan, ROC.
Zhonghua Yi Xue Za Zhi (Taipei). 2000 Sep;63(9):714-9.
Endometrial stromal sarcoma is a rare tumor and has unique histopathologic features. Most tumors of this kind occur in the uterus; thus, the vagina is an extremely rare site. A 34-year-old woman presented with endometrial stromal sarcoma arising in the vagina. No correlative endometriosis was found. Because of the uncommon location, this tumor was differentiated from other more common neoplasms of the vagina, particularly embryonal rhabdomyosarcoma and other smooth muscle tumors. Although the pathogenesis of endometrial stromal tumors remains controversial, the most common theory of its origin is heterotopic Müllerian tissue such as endometriosis tissue. Primitive cells of the pelvis and retroperitoneum are an alternative possible origin for the tumor if endometriosis is not present. According to the literature, the tumor has a fairly good prognosis compared with other vaginal sarcomas. Surgery combined with adjuvant radiotherapy appears to be an adequate treatment.
子宫内膜间质肉瘤是一种罕见肿瘤，具有独特的组织病理学特征。这类肿瘤大多发生于子宫，因此发生于阴道极为罕见。一名34岁女性患者出现阴道原发性子宫内膜间质肉瘤，未发现相关子宫内膜异位症。由于肿瘤位置不常见，故与其他更常见的阴道肿瘤相鉴别，尤其是胚胎性横纹肌肉瘤和其他平滑肌肿瘤。虽然子宫内膜间质肿瘤的发病机制仍存在争议，但其最常见的起源理论是异位苗勒组织，如子宫内膜异位症组织。若不存在子宫内膜异位症，盆腔和腹膜后的原始细胞是该肿瘤另一种可能的起源。据文献报道，与其他阴道肉瘤相比，该肿瘤预后相当良好。手术联合辅助放疗似乎是一种充分的治疗方法。
