Walsh B T, Bookheim W W, Johnson R C, Tompkins R K
Arch Intern Med. 1975 Nov;135(11):1493-7.
In order to devise a strategy for the management of acute pharyngitis, the clinical features of 418 adults with sore throat were noted and throat cultures were obtained. Patients with cultures positive for group A beta-hemolytic streptococci had a significantly higher (P less than or equal to .01) frequency of recent exposure to streptococcal infection, pharyngeal exudate, enlarged or tender cervical nodes, and high fever (greater than or equal to 38.3 C [101 F]. Patients with negative cultures complained more frequently of cough. On the basis of these symptoms and signs, a clinical algorithm was developed and discriminant function scores were computed that identify patient populations with different probabilities of having streptococcal pharyngitis. The patients with moderate and high probabilities included 91% of patients with positive cultures but only 67% of the total patient population. These methods could be the basis for more efficient evaluation of adults with sore throat.
为了制定急性咽炎的管理策略，记录了418例咽痛成人的临床特征并进行了咽拭子培养。A组β溶血性链球菌培养阳性的患者近期接触链球菌感染、咽部渗出物、颈部淋巴结肿大或压痛以及高热（≥38.3℃[101°F]）的频率显著更高（P≤0.01）。培养阴性的患者咳嗽主诉更为频繁。基于这些症状和体征，制定了一种临床算法并计算了判别函数得分，以识别患有链球菌性咽炎概率不同的患者群体。中度和高度概率的患者包括91%培养阳性的患者，但仅占总患者群体的67%。这些方法可为更有效地评估咽痛成人提供依据。
