Anderson C B, Newton W T
Arch Surg. 1975 Oct;110(10):1230-2. doi: 10.1001/archsurg.1975.01360160068011.
A series of 125 renal transplants were analyzed in order to ascertain the characteristics of accelerated allograft rejection. An intense accelerated rejection could be identified within the first five days in 12 of 67 transplants (18%) with good immediate renal function. Accelerated rejection differed from the usual acute rejection reaction by higher fever, increased duration and intensity of the rejection, and increased difficulty in reversing the reaction. Accelerated rejection was reversible and associated with satisfactory renal function one year posttransplant in 58% of patients. Lymphocytotoxic and heterophil antibodies in preoperative serum and eluates of removed kidneys were not present. Contrary to recent reports, accelerated renal allograft rejection is a potentially reversible process and not necessarily due to humoral antibody presensitization.
为了确定加速性同种异体移植排斥反应的特征，对125例肾移植进行了分析。在67例移植后即刻肾功能良好的患者中，有12例（18%）在术后头5天内出现了强烈的加速性排斥反应。加速性排斥反应与通常的急性排斥反应不同，表现为发热更高、排斥反应的持续时间和强度增加，以及逆转反应的难度增加。58%的患者加速性排斥反应是可逆的，且移植后一年肾功能良好。术前血清和切除肾脏洗脱液中不存在淋巴细胞毒性抗体和嗜异性抗体。与最近的报道相反，加速性肾同种异体移植排斥反应是一个潜在可逆的过程，不一定是由于体液抗体预致敏所致。
