Hansen L, Kristensen H L, Bek T, Ingerslev J
The Department of Ophthalmology, University Hospital Aarhus/Skejby, Aarhus, Denmark.
Acta Ophthalmol Scand. 2000 Oct;78(5):523-6. doi: 10.1034/j.1600-0420.2000.078005523.x.
To study the prevalence of risk factors for systemic thromboembolism in patients with retinal vein thrombosis (RVT).
Fifty-four patients younger than 70 years, diagnosed with a retinal vein thrombosis at the Department of Ophthalmology, Aarhus University Hospital, were examined for the presence of venous thrombosis risk factors.
23 patients had a central RVT, 26 had a branch RVT, and 4 had a macular RVT. Nineteen (35.2%) of the patients displayed increased levels of plasma homocysteine, one patient (1.9%) the Factor V Leiden mutation, and one patient (1.9%) displayed an antiphospholipid antibody. All other tests for thrombophilia rendered normal. In 15 of the patients with hyperhomocysteinemia, folic acid substitution returned plasma homocysteine to a normal value in 12 cases.
A surprisingly high prevalence of hyperhomocysteinemia was detected in this cohort of RVT patients, clearly superseding the prevalence of around 17% found in patients suffering venous thromboembolism in other vascular compartments. Our finding points to the likelihood that hyperhomocysteinemia may be a significant risk factor for retinal vein thrombosis.
研究视网膜静脉血栓形成（RVT）患者发生系统性血栓栓塞的危险因素的患病率。
对奥胡斯大学医院眼科诊断为视网膜静脉血栓形成的54例70岁以下患者进行静脉血栓形成危险因素检查。
23例患者为中央型RVT，26例为分支型RVT，4例为黄斑型RVT。19例（35.2%）患者血浆同型半胱氨酸水平升高，1例（1.9%）患者存在因子V莱顿突变，1例（1.9%）患者存在抗磷脂抗体。所有其他血栓形成倾向检测结果均正常。在15例高同型半胱氨酸血症患者中，叶酸替代治疗使12例患者的血浆同型半胱氨酸恢复正常。
在该队列RVT患者中检测到高同型半胱氨酸血症的患病率惊人地高，明显超过了在其他血管腔发生静脉血栓栓塞的患者中约17%的患病率。我们的发现表明高同型半胱氨酸血症可能是视网膜静脉血栓形成的一个重要危险因素。
