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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Salmela K, Kyllönen L

4th Department of Surgery, Helsinki University Central Hospital, Finland.

Clin Transpl. 1999:173-9.

The half-life of kidney grafts performed at Helsinki University Central Hospital has tripled from 6.5 years in 1980-84 to 17.1 years in the 1990's. 2. Delayed graft function constitutes a significant determinant of later kidney graft survival. Five-year graft survival was 81% for patients with early graft function and 71% for those with DGF. 3. High (> 350 mg/L) early (10 +/- 2 days after transplantation) cyclosporine trough levels were associated with inferior long-term graft survival. The 5-year graft survival rate was 74% compared with 86% for patients with trough levels between 250-349 mg/L. 4. Posttransplant conversion of the crossmatch test against the kidney donor, especially in association with DGF, indicates a group with significantly worse prognosis. Among 76 patients who developed antidonor antibody after transplantation, half experienced an acute rejection within 100 days and the 5-year graft survival rate was 68% compared with 83% for non-converters.

赫尔辛基大学中心医院进行的肾移植半衰期已从1980 - 1984年的6.5年增至20世纪90年代的17.1年，增长了两倍。2. 移植肾功能延迟是影响后期肾移植存活的一个重要因素。移植肾功能恢复早的患者5年移植肾存活率为81%，而移植肾功能延迟的患者为71%。3. 早期（移植后10±2天）环孢素谷值水平高（>350mg/L）与长期移植肾存活不佳相关。谷值水平在250 - 349mg/L的患者5年移植肾存活率为86%，而谷值水平>350mg/L的患者为74%。4. 肾移植后针对供肾的交叉配型试验结果转变，尤其是与移植肾功能延迟相关时，提示预后明显较差的一组患者。在76例移植后产生抗供体抗体的患者中，半数在100天内发生急性排斥反应，5年移植肾存活率为68%，而交叉配型试验结果未转变的患者为83%。

Salmela K, Kyllönen L

4th Department of Surgery, Helsinki University Central Hospital, Finland.

Clin Transpl. 1999:173-9.

The half-life of kidney grafts performed at Helsinki University Central Hospital has tripled from 6.5 years in 1980-84 to 17.1 years in the 1990's. 2. Delayed graft function constitutes a significant determinant of later kidney graft survival. Five-year graft survival was 81% for patients with early graft function and 71% for those with DGF. 3. High (> 350 mg/L) early (10 +/- 2 days after transplantation) cyclosporine trough levels were associated with inferior long-term graft survival. The 5-year graft survival rate was 74% compared with 86% for patients with trough levels between 250-349 mg/L. 4. Posttransplant conversion of the crossmatch test against the kidney donor, especially in association with DGF, indicates a group with significantly worse prognosis. Among 76 patients who developed antidonor antibody after transplantation, half experienced an acute rejection within 100 days and the 5-year graft survival rate was 68% compared with 83% for non-converters.

赫尔辛基大学中心医院进行的肾移植半衰期已从1980 - 1984年的6.5年增至20世纪90年代的17.1年，增长了两倍。2. 移植肾功能延迟是影响后期肾移植存活的一个重要因素。移植肾功能恢复早的患者5年移植肾存活率为81%，而移植肾功能延迟的患者为71%。3. 早期（移植后10±2天）环孢素谷值水平高（>350mg/L）与长期移植肾存活不佳相关。谷值水平在250 - 349mg/L的患者5年移植肾存活率为86%，而谷值水平>350mg/L的患者为74%。4. 肾移植后针对供肾的交叉配型试验结果转变，尤其是与移植肾功能延迟相关时，提示预后明显较差的一组患者。在76例移植后产生抗供体抗体的患者中，半数在100天内发生急性排斥反应，5年移植肾存活率为68%，而交叉配型试验结果未转变的患者为83%。