[Inhibition of angiogenesis with antisense ODN of VEGF].

OBJECTIVE

To investigate whether antisense oligodeoxynucletides(ODNs) of VEGF can become a kind of drugs for antitumor cancer treatment.

METHODS

With a tumor model on the cornea of the mouse the inhibition of angiogenesis and tumor growth by 5 ODNs with different modifications and sequences was determined.

RESULTS

ODNs with partial phosphorothioate modification, or with hairpin structure could effectively inhibit tumor-induced angiogenesis, but the linear ODN could not. The use of 2 ODNs at different sites gave the best results.

CONCLUSION

VEGF antisense ODNs can hopefully become new drug with antitumor and antiangiogenesis activities.