Chen S, Xiao L, Zou X
Department of Hematology, Guangdong Provincial People's Hospital, Guangzhou.
Zhonghua Yi Xue Za Zhi. 1998 Nov;78(11):824-6.
To explore the relationship between the effects of platelet transfusion and histocompatibility antigen (HLA).
The relationship between the corrected count increment (CCI) of platelet with lymphocytotoxicity test (LCT) and human histocompatibity antigen system-I subtype (HLA-I) in 126 hospitalized patients who accepted platelet transfusion.
Ineffective platelet transfusion was strongly related to LCT positive and LCT intensity (P < 0.01). The HLA A2 gene frequency was 0.91. The frequency was much higher than that of health human being (0.54).
Positive LCT was mainly immune factor for ineffective platelet transfusion. CCI and LCT should be the routine test for platelet patients. It may improve the effects of platelet transfusion.
探讨血小板输注效果与组织相容性抗原（HLA）之间的关系。
对126例接受血小板输注的住院患者，分析血小板校正计数增加值（CCI）与淋巴细胞毒性试验（LCT）及人类组织相容性抗原系统-Ⅰ亚型（HLA-Ⅰ）之间的关系。
血小板输注无效与LCT阳性及LCT强度密切相关（P<0.01）。HLA A2基因频率为0.91，该频率远高于健康人群（0.54）。
LCT阳性是血小板输注无效的主要免疫因素。CCI和LCT应作为血小板患者的常规检测项目，这可能会提高血小板输注效果。
