褪黑素对吗啡依赖小鼠吗啡戒断综合征及血清单胺的抑制作用
[The inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice].
作者信息
Qiu Y, Kang L, Qiu X
机构信息
Department of Physiology, Beijing Medical University.
出版信息
Zhonghua Yi Xue Za Zhi. 1998 Sep;78(9):704-6.
OBJECTIVE
To observe the inhibitory effect of melatonin on morphine withdrawal syndromes and serum monoamines in morphine dependent mice.
METHODS
A physical dependent model in mice was established by subcutaneous injection of morphine. The intensity of withdrawal syndromes was evaluated according to the jumping latency and jumping times. The concentration of serum monoamines was detected with HPLC-ECD.
RESULTS
The physical withdrawal syndromes in morphine dependent mice were inhibited partly by four different doses (25, 50, 100, 200 mg/kg) of melatonin and showed a significant dose-dependent manner. The increased concentration of serum norepinephrine and dopamine in morphine-dependent mice could be reduced by large dose (100 mg/kg) of melatonin.
CONCLUSION
The jumping withdrawal syndromes and serum monoamiues in morphine-dependent mice could be inhibited partly by melatonin.
目的
观察褪黑素对吗啡依赖小鼠吗啡戒断综合征及血清单胺类物质的抑制作用。
方法
通过皮下注射吗啡建立小鼠身体依赖模型。根据跳跃潜伏期和跳跃次数评估戒断综合征的强度。采用高效液相色谱-电化学检测法测定血清单胺类物质的浓度。
结果
四种不同剂量（25、50、100、200 mg/kg）的褪黑素均可部分抑制吗啡依赖小鼠的身体戒断综合征，且呈显著的剂量依赖性。大剂量（100 mg/kg）的褪黑素可降低吗啡依赖小鼠血清去甲肾上腺素和多巴胺浓度的升高。
结论
褪黑素可部分抑制吗啡依赖小鼠的跳跃性戒断综合征及血清单胺类物质。
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