[磺脲类受体基因多态性与中国人群非胰岛素依赖型糖尿病相关]

[Sulfonylurea receptor gene polymorphism is associated with non-insulin dependent diabetes mellitus in Chinese population].

作者信息

Ji L, Han X, Wang H

机构信息

Department of Endocrinology, People's Hospital, Beijing Medical University.

出版信息

Zhonghua Yi Xue Za Zhi. 1998 Oct;78(10):774-5.

PMID:11038833

Abstract

OBJECTIVE

To test the role of Sulfonylurea receptor gene(SUR) in the pathogenesis of NIDDM in Chinese population.

METHODS

We studied the polymorphisms of the SUR gene in intron 24 and exon 22 by polymerase chain reaction(PCR) and appropriate restriction enzyme (PCR-RFLP) in 86 NIDDM patients with at least two first degree diabetic relatives and 148 normal control subjects.

RESULTS

The frequency of "c" allele of intron 24 in NIDDM patients was significantly increased as compared with that in the control subjects (68.02% vs. 55.41, P = 0.007), and the frequency of the "cc" genotype of intron 24 in the NIDDM group was also significantly higher than that in the control group (41.86% vs. 27.7%, P = 0.013, OR = 4.39, CI: 1.52-12.66). The polymorphism of exon 22 described in the Caucasian population was not detected.

CONCLUSION

The association of the polymorphism of SUR gene with NIDDM in different races suggests that the SUR gene or nearby gene may play an important role in the genetic susceptibility of NIDDM.

摘要

目的

检测磺脲类受体基因（SUR）在中国人群非胰岛素依赖型糖尿病（NIDDM）发病机制中的作用。

方法

我们采用聚合酶链反应（PCR）及合适的限制性内切酶（PCR-RFLP）技术，研究了86例至少有两名一级糖尿病亲属的NIDDM患者及148例正常对照者SUR基因第24内含子和第22外显子的多态性。

结果

与对照组相比，NIDDM患者第24内含子“c”等位基因频率显著升高（68.02%对55.41%，P = 0.007），NIDDM组第24内含子“cc”基因型频率也显著高于对照组（41.86%对27.7%，P = 0.013，OR = 4.39，CI：1.52 - 12.66）。未检测到白种人人群中描述的第22外显子的多态性。