Dyer D L, Shinder A, Shinder F
Research Division, Woodward Laboratories, Los Alamitos, Calif., USA.
Fam Med. 2000 Oct;32(9):633-8.
BACKGROUND AND HYPOTHESES: A substantial percentage of school absenteeism among children is related to transmissible infection. Rates of transmission can be reduced by hand washing with soap and water, but such washing occurs infrequently. This study tested whether an alcohol-free instant hand sanitizer (CleanHands) could reduce illness absenteeism in school-age children.
A 10-week, open-label, crossover study was performed on 420 elementary school-age children (ages 5-12). Students were given a brief orientation immediately prior to the start of the study on the relationship of germs, illness, and hand washing. Each student in the treatment group then received the test product in individual bottles, with instructions to apply one to two sprays to the hands after coming into the classroom, before eating, and after using the restroom, in addition to their normal hand washing with soap and water. The control group was instructed to continue hand washing as normal with non-medicated soap. After 4 weeks of treatment and a 2-week wash-out period, the control and experimental groups were reversed. Data gathered on absenteeism were classified as gastrointestinal or respiratory related and normalized for nonillness-related absenteeism and school holidays.
Compared to the hand washing-only control group, students using CleanHands were found to have 41.9% fewer illness-related absence days, representing a 28.9% and a 49.7% drop in gastrointestinal- and respiratory-related illnesses, respectively. Likewise, absence incidence decreased by 31.7%, consisting of a 44.2% and 50.2% decrease in incidence of gastrointestinal- and respiratory-related illnesses, respectively. No adverse events were reported during the study.
Daily use of the instant hand sanitizer was associated with significantly lower rates of illness-related absenteeism.
背景与假设:儿童中相当大比例的缺课与传染性感染有关。用肥皂和水洗手可降低传播率,但这种洗手行为并不常见。本研究测试了一种不含酒精的速干洗手液(CleanHands)是否能减少学龄儿童的因病缺课情况。
对420名小学学龄儿童(5 - 12岁)进行了一项为期10周的开放标签交叉研究。在研究开始前,学生们接受了关于细菌、疾病和洗手关系的简短培训。然后,治疗组的每个学生都收到单独瓶装的测试产品,并被告知除了用肥皂和水正常洗手外,在进入教室后、吃饭前和使用卫生间后,向手上喷一到两下。对照组被指示继续用普通肥皂正常洗手。经过4周的治疗和2周的洗脱期后,对照组和实验组互换。收集的缺课数据被分类为与胃肠道或呼吸道相关,并针对与疾病无关的缺课和学校假期进行了标准化处理。
与仅用肥皂洗手的对照组相比,使用CleanHands的学生因病缺课天数减少了41.9%,胃肠道相关疾病和呼吸道相关疾病分别下降了28.9%和49.7%。同样,缺课发生率下降了31.7%,胃肠道相关疾病和呼吸道相关疾病的发生率分别下降了44.2%和50.2%。研究期间未报告不良事件。
每日使用速干洗手液与因病缺课率显著降低有关。