一名类风湿关节炎患者因类风湿结节的金黄色葡萄球菌感染导致败血症，进而出现横纹肌溶解和关节炎加重；这是一个灾难性的后果。

Rhabdomyolysis and aggravation of arthritis in a rheumatoid arthritis patient as a result of sepsis due to Staphylococcus aureus infection of a rheumatoid nodule; a catastrophic outcome.

作者信息

Saito H, Miyata M, Ito M, Katakura K, Shishido H, Orikasa H, Munakata O, Saka M, Nishimaki T, Uchiyama T, Kasukawa R

机构信息

Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima City, Japan.

出版信息

Fukushima J Med Sci. 1999 Dec;45(2):125-33.

PMID:11039609

Abstract

A 63-year-old man with rheumatoid arthritis presented with rhabdomyolysis and intractable arthritis of acute onset. He was diagnosed to have sepsis due to Staphylococcus aureus infection through of an ulcerated rheumatoid nodule. Staphylococcus aureus isolated from pus in the ulcerated rheumatoid nodule and a blood sample obtained from the heart post-mortem produced the toxic shock syndrome toxin-1 (TSST-1). The TSST-1 and/or unmethylated CpG motifs in the oligonucleotides present in a bacterium, Staphylococcus aureus in this case, might be implicated in the induction of rhabdomyolysis and intractable arthritis.

摘要

一名63岁的类风湿性关节炎男性患者出现横纹肌溶解和急性发作的难治性关节炎。通过溃疡性类风湿结节，他被诊断为金黄色葡萄球菌感染所致的脓毒症。从溃疡性类风湿结节的脓液中分离出的金黄色葡萄球菌以及死后从心脏采集的血样中均产生了毒性休克综合征毒素-1（TSST-1）。在这种情况下，金黄色葡萄球菌中的TSST-1和/或寡核苷酸中未甲基化的CpG基序可能与横纹肌溶解和难治性关节炎的诱导有关。