慢性酒精中毒患者脂质、蛋白质氧化增加及DNA损伤
Increased lipid and protein oxidation and DNA damage in patients with chronic alcoholism.
作者信息
Mutlu-Türkoğlu U, Doğru-Abbasoğlu S, Aykaç-Toker G, Mirsal H, Beyazyürek M, Uysal M
机构信息
Department of Biochemistry, Faculty of Medicine, University of Istanbul, and the Anatolia Clinics, Balikli Rum Hospital, Turkey.
出版信息
J Lab Clin Med. 2000 Oct;136(4):287-91. doi: 10.1067/mlc.2000.109097.
Increased oxidative stress has been speculated to be one possible mechanism of ethanol toxicity. This study evaluates malondialdehyde (MDA) and protein carbonyl content in serum as markers of oxidative stress and DNA damage in lymphocytes in the same patients with chronic alcoholism. Patients with chronic alcoholism showed a significant increase in MDA levels and protein carbonyl content of their serum as compared with non-alcoholic control subjects. Increases in endogenous and H2O2-induced DNA damage were also observed in lymphocytes of patients with chronic alcoholism. In addition, there were significant correlations between endogenous and H2O2-induced DNA damage and serum MDA or protein carbonyl content in patients with chronic alcoholism. These results clearly indicate the presence of oxidative stress in patients with chronic alcoholism.
氧化应激增加被推测为乙醇毒性的一种可能机制。本研究评估了慢性酒精中毒患者血清中丙二醛（MDA）和蛋白质羰基含量，作为氧化应激和淋巴细胞DNA损伤的标志物。与非酒精对照受试者相比，慢性酒精中毒患者血清中的MDA水平和蛋白质羰基含量显著增加。在慢性酒精中毒患者的淋巴细胞中也观察到内源性和H2O2诱导的DNA损伤增加。此外，慢性酒精中毒患者内源性和H2O2诱导的DNA损伤与血清MDA或蛋白质羰基含量之间存在显著相关性。这些结果清楚地表明慢性酒精中毒患者存在氧化应激。
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