Plesník V, Machálek J
Krajská hygienická stanice, Ostrava.
Epidemiol Mikrobiol Imunol. 2000 Aug;49(3):103-9.
In the course of 20 years in collaboration with dermatologists and doctors attending adolescents 75 patients were treated suffering for at least four years from 10 relapses of herpes labialis or genitalis every year. The usual treatment mitigated only temporarily their complaints but had no effect on the frequency of relapses. Two thirds of the patients had immunological examinations, in half of them shortage of IgA was found. Only 12 subjects had during comprehensive immunological examinations normal results. After 3-4 years immunomodulation with poliovaccine in rare instances combined with other immune preparations, the condition improved in 67 of 69 patients (97%), in two (3%) it remained unaltered. The procedure involved restricted exposure to tobacco smoke, alcohol, UV rays and sleep deficiency. After a comprehensive immunological examination immunomodulation with levamisol was started. This was followed by the administration of 2-3 drops of poliovaccine, at first every month, when the complaints receded the interval of vaccine administration was prolonged. When the complaints persisted the immunity of the organism was promoted by protection from influenza (vaccination, Remantadin) and other respiratory infections (Isoprinosin, Modimunal) and the general resistance was reinforced (Biostim). The mentioned procedure should be reserved for subjects with herpes persisting for a long time and with frequently relapsing herpes.
在与皮肤科医生及诊治青少年的医生合作的20年期间，对75例患者进行了治疗，这些患者每年至少复发10次唇疱疹或生殖器疱疹，病程至少4年。常规治疗只能暂时缓解他们的症状，但对复发频率没有影响。三分之二的患者进行了免疫学检查，其中一半发现IgA缺乏。只有12名受试者在全面的免疫学检查中结果正常。经过3 - 4年用脊髓灰质炎疫苗进行免疫调节，少数情况下联合其他免疫制剂，69例患者中有67例（97%）病情改善，2例（3%）病情未改变。该治疗过程包括限制接触烟草烟雾、酒精、紫外线和睡眠不足。在全面的免疫学检查后，开始用左旋咪唑进行免疫调节。随后给予2 - 3滴脊髓灰质炎疫苗，起初每月一次，当症状减轻时延长疫苗给药间隔。当症状持续时，通过预防流感（接种疫苗、服用金刚烷胺）和其他呼吸道感染（服用异丙肌苷、莫迪蒙）来增强机体免疫力，并增强全身抵抗力（服用生物刺激素）。上述治疗方法应仅用于疱疹持续时间长且频繁复发的患者。
