逆转录病毒载体
Retroviral vectors.
作者信息
Kurian K M, Watson C J, Wyllie A H
机构信息
Sir Alistair Currie CRC Laboratories, Western General Hospital, Edinburgh, UK.
出版信息
Mol Pathol. 2000 Aug;53(4):173-6. doi: 10.1136/mp.53.4.173.
Abstract
Traditionally, the retrovirus is regarded as an enemy to be overcome. However, for the past two decades retroviruses have been harnessed as vehicles for transferring genes into eukaryotic cells, a process known as transduction. During this time, the technology has moved from being a scientific laboratory tool to a potential clinical molecular medicine to be used in gene therapy. This review explains the strategy for harnessing the retrovirus life cycle, the scientific research and clinical applications of this methodology, and its limitations, as well as possible future developments.
摘要
传统上，逆转录病毒被视为一种需要克服的敌人。然而，在过去的二十年里，逆转录病毒已被用作将基因导入真核细胞的载体，这一过程称为转导。在此期间，这项技术已从一种科学实验室工具发展成为一种可用于基因治疗的潜在临床分子医学。这篇综述解释了利用逆转录病毒生命周期的策略、该方法的科学研究和临床应用、其局限性以及可能的未来发展。
相似文献
1
Retroviral vectors.逆转录病毒载体
Mol Pathol. 2000 Aug;53(4):173-6. doi: 10.1136/mp.53.4.173.
2
Progress with retroviral gene vectors.逆转录病毒基因载体的进展。
Rev Med Virol. 2000 May-Jun;10(3):185-202. doi: 10.1002/(sici)1099-1654(200005/06)10:3<185::aid-rmv285>3.0.co;2-8.
3
Retrovirus-mediated gene transfer in cancer therapy.逆转录病毒介导的基因转移在癌症治疗中的应用
Pharmacol Ther. 1994 Sep;63(3):323-47. doi: 10.1016/0163-7258(94)90029-9.
4
Retroviral vectors. From laboratory tools to molecular medicine.逆转录病毒载体：从实验室工具到分子医学
Mol Biotechnol. 1996 Apr;5(2):139-58. doi: 10.1007/BF02789062.
5
Retroviruses as vectors.逆转录病毒作为载体。
Br Med Bull. 1995 Jan;51(1):12-30. doi: 10.1093/oxfordjournals.bmb.a072941.
6
Retrovirus vectors.
Contrib Nephrol. 2008;159:30-46. doi: 10.1159/000125574.
7
Retroviral protein transfer: falling apart to make an impact.逆转录病毒蛋白转移：解体以产生影响。
Curr Gene Ther. 2012 Oct;12(5):389-409. doi: 10.2174/156652312802762581.
8
Pseudotyped Viruses for Retroviruses.伪型病毒用于逆转录病毒。
Adv Exp Med Biol. 2023;1407:61-84. doi: 10.1007/978-981-99-0113-5_4.
9
Development of retroviral vectors as safe, targeted gene delivery systems.逆转录病毒载体作为安全、靶向性基因递送系统的开发。
J Mol Med (Berl). 1996 Apr;74(4):171-82. doi: 10.1007/BF00204747.
10
Introduction to retroviruses and retroviral vectors.
Somat Cell Mol Genet. 2001 Nov;26(1-6):1-11. doi: 10.1023/a:1021014728217.
引用本文的文献
1
Gene and Cell Therapy for Sarcomas: A Review.肉瘤的基因与细胞治疗综述
Cancers (Basel). 2025 Mar 27;17(7):1125. doi: 10.3390/cancers17071125.
2
The Genetic and Biological Basis of Pseudoarthrosis in Fractures: Current Understanding and Future Directions.骨折后假关节形成的遗传和生物学基础：当前认识与未来方向
Diseases. 2025 Mar 3;13(3):75. doi: 10.3390/diseases13030075.
3
Enhancing Proliferation of Stem Cells from Human Exfoliated Deciduous Teeth (SHED) through hTERT Expression while Preserving Stemness and Multipotency.通过hTERT表达增强人脱落乳牙干细胞（SHED）的增殖，同时保持干性和多能性。
Stem Cell Rev Rep. 2024 Oct;20(7):1902-1914. doi: 10.1007/s12015-024-10746-y. Epub 2024 Jun 15.
4
A comprehensive literature scoping review of infection prevention and control methods for viral-mediated gene therapies.病毒介导基因治疗感染预防与控制方法的全面文献综述。
Antimicrob Steward Healthc Epidemiol. 2024 Jan 31;4(1):e15. doi: 10.1017/ash.2024.1. eCollection 2024.
5
Viral Vector Systems for Gene Therapy: A Comprehensive Literature Review of Progress and Biosafety Challenges.用于基因治疗的病毒载体系统：进展与生物安全挑战的综合文献综述
Appl Biosaf. 2020 Mar 1;25(1):7-18. doi: 10.1177/1535676019899502.
6
Engineered Zinc Finger Protein Targeting 2LTR Inhibits HIV Integration in Hematopoietic Stem and Progenitor Cell-Derived Macrophages: In Vitro Study.工程化锌指蛋白靶向 2LTR 抑制造血干细胞和祖细胞衍生巨噬细胞中的 HIV 整合：体外研究。
Int J Mol Sci. 2022 Feb 19;23(4):2331. doi: 10.3390/ijms23042331.
7
Mucopolysaccharidoses type I gene therapy.黏多糖贮积症 I 型基因治疗。
J Inherit Metab Dis. 2021 Sep;44(5):1088-1098. doi: 10.1002/jimd.12414. Epub 2021 Jul 9.
8
A review of the underlying genetics and emerging therapies for canine cardiomyopathies.犬心肌病的潜在遗传学和新兴治疗方法综述。
J Vet Cardiol. 2022 Apr;40:2-14. doi: 10.1016/j.jvc.2021.05.003. Epub 2021 May 21.
9
CRISPR-Cas9 DNA Base-Editing and Prime-Editing.CRISPR-Cas9 DNA 碱基编辑和先导编辑。
Int J Mol Sci. 2020 Aug 28;21(17):6240. doi: 10.3390/ijms21176240.
10
Gene therapy for atrial fibrillation - How close to clinical implementation?心房颤动的基因治疗 - 离临床应用还有多远？
Int J Cardiol. 2019 Dec 1;296:177-183. doi: 10.1016/j.ijcard.2019.07.057. Epub 2019 Aug 7.
本文引用的文献
1
The greater good: fetuses destined for abortion may be used to test gene therapy.更大的利益：注定要被堕胎的胎儿可用于测试基因疗法。
New Sci. 1998 Oct 10;160(2155):5.
2
P53 tumor suppressor gene therapy for cancer.用于癌症治疗的P53肿瘤抑制基因疗法。
Cancer Gene Ther. 1998 Jan-Feb;5(1):52-63.
3
Science, medicine, and the future. Gene therapy.科学、医学与未来。基因治疗。
BMJ. 1997 Nov 15;315(7118):1289-92. doi: 10.1136/bmj.315.7118.1289.
4
Overcoming the obstacles to gene therapy.克服基因治疗的障碍。
Sci Am. 1997 Jun;276(6):96-101.
5
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus.附加型载体能快速稳定地产生高滴度重组逆转录病毒。
Hum Gene Ther. 1996 Aug 1;7(12):1405-13. doi: 10.1089/hum.1996.7.12-1405.
6
Inducible gene expression by retrovirus-mediated transfer of a modified tetracycline-regulated system.通过逆转录病毒介导转移改良的四环素调控系统实现可诱导基因表达。
J Virol. 1996 Sep;70(9):6054-9. doi: 10.1128/JVI.70.9.6054-6059.1996.
7
Applications of retrovirus-mediated expression cloning.逆转录病毒介导的表达克隆的应用。
Exp Hematol. 1996 Feb;24(2):324-9.
8
Targeting of retroviral vectors for gene therapy.用于基因治疗的逆转录病毒载体靶向性
Hum Gene Ther. 1993 Apr;4(2):129-41. doi: 10.1089/hum.1993.4.2-129.
9
Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus.致肿瘤逆转录病毒需要经历有丝分裂，而人类免疫缺陷病毒则不需要。
J Virol. 1994 Jan;68(1):510-6. doi: 10.1128/JVI.68.1.510-516.1994.
10
Lineage analysis using retrovirus vectors.使用逆转录病毒载体进行谱系分析。
Methods Enzymol. 1993;225:933-60. doi: 10.1016/0076-6879(93)25059-b.
Zotero 插件